Antisecretory and Antiulcer Activity of Acacia Catechu against Indomethacin plus Pyloric Ligation Induced Gastric Ulcers in Rats

Study was aimed to evaluate the possible antisecretory and antiulcer activity of crude bark extract of Acacia catechu and its action against indomethacin an non steroidal anti inflammatory drug (NSAID) plus pyloric ligation induced gastric ulcers in rats. Administration of crude extract of Acacia catechu (400mg/kg/day p.o.) significantly reduced ulcer index when compared with indomethacin induced gastric ulcerative rats. Ranitidine (30 mg/kg/day p.o.) was used as the reference antiulcer drug. Extract treated animals also significantly reduced volume of gastric secreation, free acidity and total acidity. A significant increase in total carbohydrate (TC) / total protein (TP) ratio of gastric juice was also observed. No significant change in the total protein was noted during the study. Acacia catechu was found to be an effective antiulcerogenic agent. The result of this study suggests that Acacia catechu cause an inhibitory effect on release gastric hydrochloric acids and protects gastric mucosal damage.